Smoking has serious health consequences, and the risk of relapse during an attempt to quit is high. A treatment that leads to successful, lasting smoking cessation has not yet been developed. A new brain stimulation technique (deep TMS) targeting the insula appears to be a promising treatment strategy. Given the functional lateralization of the insula and sex-dependent differences in addiction and cognition, it is important to unravel the differential effects of left- and right insula stimulation in terms of smoking cessation, craving, and related neurocognitive mechanisms.

In a clinical trial, 112 heavy smokers (male/female) are randomized to active (left/right) or sham stimulation sessions, following the viewing of smoking images. Measurements before and after the intervention consist of behavioral measurements (questionnaires, tasks), neuroimaging ((f)MRI, MRS), and qualitative interviews. Results of the study may contribute to personalized treatment strategies, optimized per patient based on neurocognitive profile and sex.

This project offers you the opportunity to gain experience with both quantitative and qualitative research methods by employing various techniques, including questionnaire administration, behavioral computer tasks, neuroimaging (fMRI, MRS), and qualitative interviews.

As an intern in our group, you will play an important role in the progress of the RCT. The clinical trial will primarily be conducted at Amsterdam UMC – location VUmc, meaning you will need to be in Amsterdam frequently.

Please contact us if you want more information and want to join the team!